UPB
Upstream Bio, Inc.NASDAQ
Healthcare • Biotechnology
Updated 1 day ago
Coverage limited
Factor tilt: Anti-Quality Micro Cap
$3.55-14.87%
Close Oct 13, 2026
- Market cap
- $193.19M
- 1 month
- -38.9%
- 3 months
- -51.2%
- 1 year
- -81.9%
- 52-week range
- $3.55$32.60
- Dividend
- No dividends on record
- Next-quarter EPS estimate
- -$0.73Quarter to Sep 30, 2026 · 8 analysts · revenue $480.29K
- Short interest
- 10.5% of float4.5M shares · settled Sep 30, 2026 · +0.5% since Sep 15, 2026 · FINRA
Fundamentals · trailing 12 months to Jun 30, 2026
- Revenue
- $3.16M
- Net income
- -$156.5M
- Free cash flow
- -$136.34M
- Book value
- $270.96M
- Total debt
- $954K
- P/E
- —
- Price / sales
- 61.2×
- Price / book
- 0.7×
- FCF yield
- -70.6%
- Net margin
- -4,955.7%
EODHD (TTM) · as of Oct 13, 2026
End-of-day close from stored market data, not a live quote.
Portfolio context
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Loading market dates
No upcoming ex-dividend date announced
No 8-K filings in the last 30 days.
Smart money context
Holder IQ: MEDIUM
30 top institutions tracked
as of 2026-Q2 (filed 2026-09-22)
Last 13F trend: distributing (heavy)
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Sentiment: bearish
Last trade: sell 28 days ago
Red flags: 0
Largest 13-F holders · Q2 2026
148 filers reported a long position in UPB for Q2 2026. 13-F holdings are filed up to 45 days after the quarter ends.
| Holder | Value | Shares | Shares vs Q1 2026 |
|---|---|---|---|
| FMR LLC | $56.5M | 8.2M | +0.8% |
| ORBIMED ADVISORS LLC | $39.4M | 5.7M | Unchanged |
| NORGES BANK | $26.1M | 3.8M | — |
| BlackRock, Inc. | $26M | 3.8M | +11.4% |
| Decheng Capital LLC | $18.9M | 2.7M | Unchanged |
| Enavate Sciences GP, LLC | $17M | 2.5M | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC | $13M | 1.9M | +0.2% |
| MILLENNIUM MANAGEMENT LLC | $7.9M | 1.1M | +22% |
| D. E. Shaw & Co., Inc. | $7.2M | 1M | +26.3% |
| JPMORGAN CHASE & CO | $7M | 1M | +118.6% |
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