ANAPTYSBIO INC

Rule 10b5-1 Trading Arrangements

On June 10, 2024, Paul Lizzul, chief medical officer of the Company, entered into a written plan for the potential sale of up to an aggregate 36,500 shares of common stock (the “New Lizzul 10b5-1 Plan”). No trades will occur under the New Lizzul 10b5-1 Plan prior to the termination of Mr. Lizzul’s existing rule 10b5-1 plan, pursuant to its terms. The plan is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c) under the Exchange Act and is scheduled to terminate no later than June 10, 2025.

On June 10, 2024, Eric Loumeau, chief legal officer of the Company, entered into a written plan for the potential sale of up to an aggregate 77,045 shares of common stock (the “New Loumeau 10b5-1 Plan”). The aggregate number of shares that will be sold under the New Loumeau 10b 5-1 Plan is not yet determinable because the shares available will be net of shares sold to satisfy tax withholding obligations that arise in connection with the vesting and settlement of such restricted stock unit awards. As such, for purposes of this disclosure, the aggregate number of shares of common stock available for sale reflects the aggregate maximum number of shares underlying Mr. Loumeau’s restricted stock units which may be sold, without excluding the shares that will be sold to satisfy the tax withholding obligations. No trades will occur under the New Loumeau 10b5-1 Plan prior to the termination of Mr. Loumeau’s existing 10b5-1 plan, pursuant to its terms. The plan is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c) under the Exchange Act and is scheduled to terminate no later than June 30, 2025.

On June 14, 2024, Dennis Mulroy, chief financial officer of the Company, entered into a written plan for the potential sale of up to an aggregate 62,350 shares of common stock (the “New Mulroy 10b5-1 Plan”). The aggregate number of shares that will be sold under the New Mulroy 10b 5-1 Plan is not yet determinable because the shares available will be net of shares sold to satisfy tax withholding obligations that arise in connection with the vesting and settlement of such restricted stock unit awards. As such, for purposes of this disclosure, the aggregate number of shares of common stock available for sale reflects the aggregate maximum number of shares underlying Mr. Mulroy’s restricted stock units which may be sold, without excluding the shares that will be sold to satisfy the tax withholding obligations. No trades will occur under the New Mulroy 10b5-1 Plan prior to the termination of Mr. Mulroy’s existing 10b5-1 plan, pursuant to its terms. The plan is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c) under the Exchange Act and is scheduled to terminate no later than May 15, 2025.

The plans included a representation from the officer to the broker administering the plan that the officer was not in possession of any material nonpublic information regarding the Company or the securities subject to the plan. A similar representation was made to us in connection with the adoption of the plans under our Insider Trading Policy. Those representations were made as of the date of adoption of the plans and speak only as of that date. In making those representations, there is no assurance with respect to any material nonpublic information of which the directors were unaware, or with respect to any material nonpublic information acquired by the directors or the Company after the date of the representation.

Other than as disclosed above, during the three months ended June 30, 2024, none of the Company’s directors or officers adopted orterminated any “Rule 10b5-1 trading arrangements” or any “non-Rule 10b5-1 trading arrangements,” as each term is defined in Item 408 of Regulation S-K.